Expedient deaminative phosphorylation and sulfonylation of benzylic tertiary amines enabled by difluorocarbene
Chengbo Li, Yu Guo, Jianke Su, Xinyuan Hu, Qingqing Xuan, Qiuling Song
Abstract
A deaminative functionalization of aliphatic tertiary amines via the cleavage of C(sp 3 )–N bonds under transition metal-free conditions was disclosed, which goes through S N 2 reaction with various phosphorus and sulfur nucleophiles.
Topics & Concepts
DifluorocarbeneChemistryNucleophileSulfurCleavage (geology)Organic chemistryPhosphorusSurface modificationMedicinal chemistryCombinatorial chemistryCatalysisEngineeringFracture (geology)Physical chemistryGeotechnical engineeringFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods