Design, Synthesis, and Biological Evaluation of Boron-Containing Macrocyclic Polyamines and Their Zinc(II) Complexes for Boron Neutron Capture Therapy
Hiroki Ueda, Minoru Suzuki, Reiko Kuroda, Tomohiro Tanaka, Shin Aoki
Abstract
would induce cell death upon thermal neutron irradiation, possibly via interactions with DNA.
Topics & Concepts
ChemistryBoronIntracellularCancer cellNeutron captureZincCytotoxicityRadiochemistryCancer therapyBiophysicsCancerCombinatorial chemistryIn vitroBiochemistryOrganic chemistryInternal medicineMedicineBiologyBoron Compounds in ChemistryBoron and Carbon Nanomaterials ResearchOrganoboron and organosilicon chemistry