Identification of potent and selective inhibitors of PKR via virtual screening and traditional design
Kevin P. Cusack, M.A. Argiriadi, T.D. Gordon, C.M. Harris, J. Martin Herold, Michael Z. Hoemann, B.D. Yestrepsky
Topics & Concepts
Protein kinase RChemistryPharmacophoreVirtual screeningKinaseDrug discoveryProtein kinase AEIF-2 kinaseChemical biologyComputational biologyBiochemistryBiologyMitogen-activated protein kinase kinaseCyclin-dependent kinase 2RNA regulation and diseaseRNA and protein synthesis mechanismsinterferon and immune responses