One-pot synthesis of indoles and quinolinones from <i>ortho</i>-tosylaminophenyl-substituted <i>para</i>-quinone methides
Junwei Wang, Xiang Pan, Quanjin Rong, Lei Zhao, Lin Zhao, Wei‐Chen Dai, Kun Zhao, Lihong Hu
Abstract
-quinone methides followed by an intramolecular 1,6-conjugate addition and oxidation sequence. This cascade reaction occurs readily in good yield (up to 95%), providing a divergent synthetic approach to structurally diverse 2,3-disubstituted indoles and 3,4-diaryl-substituted quinolinones.
Topics & Concepts
QuinoneAlkylationIntramolecular forceAcylationChemistryConjugateSequence (biology)Combinatorial chemistryOrganic chemistryMedicinal chemistryCatalysisMathematicsMathematical analysisBiochemistrySynthesis of Indole DerivativesBioactive Compounds and Antitumor AgentsAxial and Atropisomeric Chirality Synthesis