Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition
Grace Huang, Zhongjian Cheng, Alycia N. Hildebrand, Chunlin Wang, Maria Cimini, Rajika Roy, Anna Maria Lucchese, Cindy Benedict, Vandana Mallaredy, Ajit Magadum, Darukeshwara Joladarashi, Charan Thej, Carolina González, May Trungcao, Venkata Naga Srikanth Garikipati, John W. Elrod, Walter J. Koch, Raj Kishore
Abstract
Our findings unravel that diabetes impairs EPC-EV reparative function in the ischemic heart, at least partially, through HDACs-mediated H3K9Ac downregulation leading to transcriptional suppression of angiogenic, proliferative and cell survival genes in recipient cardiac ECs. Thus, HDAC inhibitors may potentially be used to restore the function of diabetic EPC and other stem cells for autologous cell therapy applications.
Topics & Concepts
MedicineProgenitor cellEndothelial progenitor cellAngiogenesisCardiac function curveCancer researchStem cellInternal medicineCell biologyBiologyHeart failureExtracellular vesicles in diseaseAdipokines, Inflammation, and Metabolic DiseasesImmune cells in cancer