Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles
Sarah A. Dick, Anthony Wong, Homaira Hamidzada, Sara Nejat, Robert Nechanitzky, Shabana Vohra, Brigitte Mueller, Rysa Zaman, Crystal Kantores, Laura Aronoff, Abdul Momen, Duygu Nechanitzky, Wanda Y. Li, Parameswaran Ramachandran, Sarah Q. Crome, Burkhard Becher, Myron I. Cybulsky, Filio Billia, Shaf Keshavjee, Seema Mital, Clinton S. Robbins, Tak W. Mak, Slava Epelman
Abstract
macrophages were the most transcriptionally conserved subset across mouse tissues and between mice and humans, despite organ- and species-specific transcriptional differences. Here, we define the existence of three murine macrophage subpopulations based on common life cycle properties and core gene signatures and provide a common starting point to understand tissue macrophage heterogeneity.