Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation
Hammam, Elie, Sinha, Ameya, Baumgarten, Sebastian, Nardella, Flore, Liang, Jiaqi, Miled, Samia, Bonhomme, Frédéric, Erdmann, Diane, Arcangioli, Benoit, Arimondo, Paola B, Dedon, Peter, Preiser, Peter, Scherf, Artur
Abstract
<jats:p> \n <jats:named-content content-type="genus-species">P. falciparum</jats:named-content> \n is the most virulent malaria parasite species, accounting for the majority of the disease mortality and morbidity. Understanding how this pathogen is able to adapt to different cellular and environmental stressors during its complex life cycle is crucial in order to develop new strategies to tackle the disease. \n </jats:p>
Topics & Concepts
BiologyDNA methylationMethylationPlasmodium falciparumTransfer RNAEpigeneticsGeneticsMalariaCell biologyRNAGeneGene expressionImmunologyRNA modifications and cancerHIV Research and TreatmentEpigenetics and DNA Methylation