Atypical TRAV1-2− T cell receptor recognition of the antigen-presenting molecule MR1
Wael Awad, Erin W. Meermeier, Maria L. Sandoval-Romero, Jérôme Le Nours, Aneta Worley, Megan Null, Ligong Liu, James McCluskey, David P. Fairlie, David Lewinsohn, Jamie Rossjohn
Abstract
TCRs' docking topologies on MR1. Accordingly, diverse MR1-restricted T cell repertoire reveals differential docking modalities on MR1, thus providing greater scope for differing antigen specificities.
Topics & Concepts
T-cell receptorAntigenT cellBiologyComplementarity determining regionCell biologyMolecular biologyImmunoglobulin light chainGeneticsAntibodyImmune systemImmune Cell Function and InteractionT-cell and B-cell ImmunologyCytomegalovirus and herpesvirus research