The Importance of Muscle Capillarization for Optimizing Satellite Cell Plasticity
Joshua P. Nederveen, Milan W. Betz, Tim Snijders, Gianni Parise
Abstract
Satellite cells are essential for skeletal muscle regeneration, repair, and adaptation. The activity of satellite cells is influenced by their interactions with muscle-resident endothelial cells. We postulate that the microvascular network between muscle fibers plays a critical role in satellite cell function. Exercise-induced angiogenesis can mitigate the decline in satellite cell function with age.
Topics & Concepts
SatelliteAngiogenesisSkeletal muscleRegeneration (biology)Adaptation (eye)Function (biology)Cell biologyCellBiologyNeuroscienceMyocyteCell functionAnatomyCancer researchGeneticsAerospace engineeringEngineeringMuscle Physiology and DisordersSpaceflight effects on biologyMuscle metabolism and nutrition