Bichromophoric ruthenium(<scp>ii</scp>) bis-terpyridine-BODIPY based photosensitizers for cellular imaging and photodynamic therapy
Subhadeep Paul, Sanmoy Pathak, Somarupa Sahoo, Ram Chandra Maji, Utso Bhattacharyya, Dipankar Nandi, Akhil R. Chakravarty
Abstract
multiple types of ROS production. Confocal laser scanning microscopy experiments revealed their incorporation in the cancer cells and complex 1 predominantly accumulated in lysosomes. The complexes displayed a significant PDT effect in cancerous cells with visible light activation with a high photocytotoxicity index (PI) value in HeLa cells. Both type-I and type-II photosensitization processes were involved in the PDT effect. The photodynamic action of complex 2 initiated cellular apoptosis. Finally, their diagnostic potential was evaluated against clinically relevant 3D multicellular tumor spheroids (MCTs).
Topics & Concepts
BODIPYSinglet oxygenChemistryRutheniumPhotodynamic therapyPhotobleachingTerpyridineHomolepticPhotosensitizerHeLaPhotochemistryLinkerFluorescenceBiophysicsBiochemistryIn vitroOxygenMetalOrganic chemistryCatalysisQuantum mechanicsComputer sciencePhysicsBiologyOperating systemNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine ChemistryLuminescence and Fluorescent Materials