Effects of Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles on Mouse Embryo Development, Antioxidant Enzymes and Apoptosis Genes Expression, and Ultrastructure of Sperm, Oocytes and Granulosa Cells.
Azizollah Bakhtari, Saeedeh Nazari, Sanaz Alaee, Elias Kargar-Abarghouei, Fakhroddin Mesbah, Esmaeil Mirzaei, Mohammad Jafar Molaei
Abstract
BACKGROUND: fertilization (IVF). MATERIALS AND METHODS: in the resultant blastocysts. RESULTS: in resultant blastocysts of the high-dose group and catalase and Bax in resultant blastocysts of the low-dose group, was higher than the controls. CONCLUSION: There is considerable concern regarding D-SPIONs toxic effects on IVF, and mitochondrial and cell membrane damage in mouse spermatozoa and oocytes, which may be related to oxidative stress and apoptotic events.
Topics & Concepts
AndrologyOocyteSpermBlastocystHuman fertilizationSOD1CatalaseBiologyOxidative stressApoptosisSuperoxide dismutaseCell biologyEmbryoChemistryEmbryogenesisEndocrinologyMedicineBiochemistryGeneticsSperm and Testicular FunctionNanoparticles: synthesis and applicationsReproductive Biology and Fertility