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The discovery of potent USP2/USP8 dual-target inhibitors for the treatment of breast cancer via structure guided optimization of ML364

Yucheng Tian, Kang Liu, Dongdong Wu, Liuyi Wu, Qianqian Xu, Wei Wei, Zhiyu Li, Qianming Du, Jinlei Bian

2024European Journal of Medicinal Chemistry14 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryBreast cancerCancer researchIn vivoCancerPharmacologyInternal medicineMedicineBiologyBiotechnologyUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysPeptidase Inhibition and Analysis
The discovery of potent USP2/USP8 dual-target inhibitors for the treatment of breast cancer via structure guided optimization of ML364 | Litcius