Impact of Linker Length on Biomolecular Condensate Formation
Trevor GrandPre, Yaojun Zhang, Andrew G. T. Pyo, Benjamin Weiner, Je-Luen Li, Martin C. Jonikas, Ned S. Wingreen
Abstract
Using the algal Rubisco-EPYC1 system as a model for biomolecular condensates, this study shows that the length of linker regions between interacting domains on phase-separating proteins can dramatically impact entropic costs and the propensity to form condensates.
Topics & Concepts
LinkerPhase (matter)Chemical physicsRuBisCOChemistryBiological systemBiophysicsNanotechnologyMaterials scienceComputer scienceBiologyBiochemistryOrganic chemistryOperating systemEnzymeRNA Research and SplicingProtein Structure and DynamicsHeat shock proteins research