C–H Borylation of Benzophenones Using Hydrazone as the Traceless Directing Group
Zhaoziyuan Yang, Liqiang Hao, Xiaobo Xu, Yangyang Wang, Gaorong Wu, Yafei Ji
Abstract
C-H borylation is one of the powerful C-H bond functionalization reactions. In this context, a metal-free C-H borylation of benzophenones using hydrazone as the traceless directing group has been reported. The dibromoboron intermediates can be obtained in excellent yields, and the corresponding arylboronic esters are generated in moderate to excellent yields. Furthermore, the borylated compounds can be transformed in a one-pot method, avoiding the loss of overall yield caused by the separation of the arylboronic esters.
Topics & Concepts
BorylationChemistryHydrazoneYield (engineering)Combinatorial chemistryContext (archaeology)Group (periodic table)Medicinal chemistryOrganic chemistryArylBiologyMaterials scienceMetallurgyPaleontologyAlkylCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistryCatalytic Cross-Coupling Reactions