Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction
Lipeng Chen, Linchen Lv, Lekai Zhang, Zhengdong Gao, Yaxiao Liu, Shuai Wang, Nan Zhou, Yangyang Xia, Jianfeng Cui, Xuewen Jiang, Xiulin Zhang, Yan Li, Benkang Shi
Abstract
The present study in a rat model showed that oral administration of metformin alleviated inflammation following partial bladder outlet obstruction in the early phase and ameliorated bladder fibrosis as well as bladder dysfunction by long-term treatment. Our study indicated that metformin is a potential drug to inhibit bladder remodeling and alleviate bladder dysfunction. Clinical trials are needed to validate the effect of metformin on the bladder dysfunction and bladder fibrosis in the future.
Topics & Concepts
MetforminMedicineBladder outlet obstructionUrologyFibrosisInflammationUrinary bladderInternal medicineEndocrinologyDiabetes mellitusCancerProstateUrinary Bladder and Prostate ResearchAldose Reductase and TaurineAdvanced Glycation End Products research