A convenient reagent for the conversion of aldoximes into nitriles and isonitriles
Wei Zhang, Jin‐Hong Lin, Pengfei Zhang, Ji‐Chang Xiao
Abstract
For the dehydroxylation of aldoximes with 4-nitro-1-((trifluoromethyl)sulfonyl)-imidazole (NTSI), slight modifications of reaction conditions resulted in significantly different reaction paths to provide either nitriles or isonitriles. The challenging conversion of aldoximes into isonitriles was achieved under mild conditions.
Topics & Concepts
ChemistryReagentSulfonylTrifluoromethylImidazoleNitroCombinatorial chemistryOrganic chemistryAlkylChemical Synthesis and ReactionsChemical Synthesis and AnalysisSynthesis and Catalytic Reactions