Immunothrombosis: Molecular Aspects and New Therapeutic Perspectives
María Marcos‐Jubilar, Ramón Lecumberri, José A. Páramo
Abstract
Thromboinflammation or immunothrombosis is a concept that explains the existing link between coagulation and inflammatory response present in many situations, such as sepsis, venous thromboembolism, or COVID-19 associated coagulopathy. The purpose of this review is to provide an overview of the current data regarding the mechanisms involved in immunothrombosis in order to understand the new therapeutic strategies focused in reducing thrombotic risk by controlling the inflammation.
Topics & Concepts
MedicineIntensive care medicineCoagulopathySepsisVenous thromboembolismInflammatory responseCoagulationInflammationBioinformaticsImmunologyThrombosisInternal medicineBiologyInflammasome and immune disordersNeutrophil, Myeloperoxidase and Oxidative MechanismsAtherosclerosis and Cardiovascular Diseases