Copper‐Catalyzed Remote Direct Thiocyanation of Alkyl C(<i>sp</i><sup>3</sup>)−H Bonds
Qian Wang, Peiyuan Tian, Zhong‐Yan Cao, Hongwei Zhang, Cuiyu Jiang
Abstract
Abstract A method for site‐selective intermolecular C( sp 3 )−H thiocyanation of aliphatic sulfonamides is developed using cheap trimethylsilyl isothiocyanate (TMSNCS) as the thiocyanation reagent, catalyzed by simple Cu(I)/phenanthroline complex. The mild, and modular protocol allows remote C( sp 3 )−H thiocyanation in promising yields with a broad substrate scope. magnified image
Topics & Concepts
ChemistryReagentCatalysisIsothiocyanateSubstrate (aquarium)Medicinal chemistryAlkylCombinatorial chemistryOrganic chemistryOceanographyGeologySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions