The first ring-expanded NHC–copper(<scp>i</scp>) phosphides as catalysts in the highly selective hydrophosphination of isocyanates
Thomas M. Horsley Downie, Jonathan W. Hall, Thomas P. Collier Finn, David J. Liptrot, John P. Lowe, Mary F. Mahon, Claire L. McMullin, Michael K. Whittlesey
Abstract
with isocyanates, isothiocyanates and carbon disulfide results in the insertion of the heterocumulene into the Cu-P bond. The NHC-copper phosphides were found to be the most selective catalysts yet reported for the hydrophosphination of isocyanates. They provide access to a broad range of phosphinocarboxamides in excellent conversion and good yield.
Topics & Concepts
CopperCarbeneChemistryCatalysisYield (engineering)Ring (chemistry)Polymer chemistryMedicinal chemistryDisulfide bondCarbon disulfideCombinatorial chemistryOrganic chemistryMaterials scienceMetallurgyBiochemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques