Response to Comment on “Structural evidence for a dynamic metallocofactor during N <sub>2</sub> reduction by Mo-nitrogenase”
Wonchull Kang, Chi Chung Lee, Andrew J. Jasniewski, Markus W. Ribbe, Yilin Hu
Abstract
Peters et al . comment on our report of the dynamic structure of the nitrogenase metallocofactor during N 2 reduction. Their claim that their independent structural refinement and consideration of biochemical data contradict our finding is incorrect and is strongly refuted by our biochemical and structural data that collectively and conclusively point to the binding of dinitrogen species to the nitrogenase cofactor.
Topics & Concepts
NitrogenaseReduction (mathematics)CofactorChemistryComputational chemistryNitrogen fixationBiochemistryEnzymeMathematicsOrganic chemistryNitrogenGeometryAmmonia Synthesis and Nitrogen ReductionMetalloenzymes and iron-sulfur proteinsHydrogen Storage and Materials