Atazanavir Resensitizes Candida auris to Azoles
Yehia Elgammal, Ehab A. Salama, Mohamed N. Seleem
Abstract
Candida auris represents an urgent health threat. Here, we identified atazanavir as a potent drug capable of resensitizing C. auris clinical isolates to the activity of azole antifungals.
Topics & Concepts
AtazanavirCandida aurisItraconazolePharmacologyAzoleEffluxRitonavirMedicineChemistryMicrobiologyAntifungalBiologyVirologyBiochemistryHuman immunodeficiency virus (HIV)Antiretroviral therapyViral loadAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatmentHIV/AIDS drug development and treatment