Recent Studies of Bifunctionalization of Simple Indoles
Zhan‐Yong Wang, Shaohong Xu, Kai‐Kai Wang, Niuniu Kong, Xue Liu
Abstract
Abstract Indole structures are extremely important and widely employed in organic synthesis. This review will focus on direct bifunctionalizations of simple indoles in tandem reactions. Recent studies have been divided into four types by trigger mechanisms: (1) nucleophilic C3; (2) nucleophilic NH for cyclization; (3) reduction; (4) oxidation. Reactions with carbocations, pyridines, alkenes, alkynes, aldehydes, imines, halogenated compounds et al were discussed. We hope this review will promote future research in the use of indoles.
Topics & Concepts
ChemistryCarbocationNucleophileIndole testNucleophilic additionCombinatorial chemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsSynthesis of Indole DerivativesSynthesis and Catalytic Reactions