A double-tetrahedral DNA framework based electrochemical biosensor for ultrasensitive detection and release of circulating tumor cells
Chenguang Wang, Yi Xu, Xiaoshuang Zhao, Shuainai Li, Qiuling Qian, Wei Wang, Xianqiang Mi
Abstract
MCF-7 cells with an ultralow detection limit of 1 cell. The release efficiency reached 88.1%-97.6% and the viability of the released cells reached up to 98%. We also detected the MCF-7 cells in mimic whole blood samples, suggesting that the E-CTC sensor system shows promise for use in clinical research.
Topics & Concepts
Horseradish peroxidaseAptamerCirculating tumor cellDetection limitBiosensorNucleaseDNAChemistryLinear rangeBiophysicsElectrodeCancer cellNanotechnologyBiotinMolecular biologyCombinatorial chemistryMaterials scienceBiochemistryChromatographyCancerEnzymeBiologyPhysical chemistryMetastasisGeneticsAdvanced biosensing and bioanalysis techniquesNanopore and Nanochannel Transport StudiesRNA Interference and Gene Delivery