Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein
K. Yeon Choi, Nadia S. El‐Hamdi, Alistair McGregor
Abstract
Congenital CMV is a leading cause of cognitive impairment and deafness in newborns, and a vaccine is a high priority. The only small animal model for congenital CMV is the guinea pig and guinea pig cytomegalovirus (GPCMV) encoding functional HCMV homolog viral glycoprotein complexes necessary for cell entry that are neutralizing-antibody vaccine targets.
Topics & Concepts
Viral tegumentBiologyLytic cyclePentamerVirologyCytomegalovirusGuinea pigHuman cytomegalovirusCell biologyHerpesviridaeVirusViral diseaseEndocrinologyBiochemistryCytomegalovirus and herpesvirus researchHerpesvirus Infections and TreatmentsMosquito-borne diseases and control