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Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS

Jie Zhao, Qingya Shen, Xihao Yong, Xin Li, Xiaowen Tian, Suyue Sun, Zheng Xu, Xiaoyu Zhang, Lu Zhang, Hao Yang, Zhenhua Shao, Haoxing Xu, Yiyang Jiang, Yan Zhang, Wei Yan

2025Nature Structural & Molecular Biology11 citationsDOI

Topics & Concepts

mTORC1CholesterolCell biologyLysosomeG protein-coupled receptorBiologyBiochemistryFunction (biology)ChemistryBiophysicsSignal transductionPI3K/AKT/mTOR pathwayEnzymeCellular transport and secretionNeurobiology and Insect Physiology ResearchLipid Membrane Structure and Behavior
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS | Litcius