<i>Lactobacillus fermentum</i>F40-4 ameliorates hyperuricemia by modulating the gut microbiota and alleviating inflammation in mice
Jiayuan Cao, Ting Wang, Yisuo Liu, Wei Zhou, Haining Hao, Qiqi Liu, Boxing Yin, Huaxi Yi
Abstract
L. fermentum F40-4 could inhibit UA synthetase activity in the liver to decrease UA production, promote expression level of UA excretion transporter NPT1 in the kidney and reshape microbiota in the gut to increase UA excretion, thereby alleviate HUA.
Topics & Concepts
Lactobacillus fermentumInflammationHyperuricemiaLactobacillusGut floraMicrobiologyBiologyBacteriaChemistryImmunologyUric acidLactobacillus plantarumLactic acidBiochemistryGeneticsGout, Hyperuricemia, Uric AcidPharmacological Effects of Natural CompoundsHelicobacter pylori-related gastroenterology studies