Dipeptidyl peptidase 3 modulates the renin–angiotensin system in mice
Shalinee Jha, Ulrike Taschler, Oliver Domenig, Marko Poglitsch, Benjamin Bourgeois, Marion J. Pollheimer, Lisa M. Pusch, Grazia Malovan, Saša Frank, Tobias Madl, Karl Gruber, Robert Zimmermann, Peter Macheroux
Abstract
mice, indicating sex-specific differences. Taken together, our observations suggest that DPP3 regulates the RAS pathway and water homeostasis by degrading circulating angiotensin peptides.
Topics & Concepts
Renin–angiotensin systemDipeptidyl peptidaseDipeptidyl peptidase-4ChemistryEndocrinologyInternal medicineBiochemistryBiologyEnzymeMedicineDiabetes mellitusBlood pressureType 2 diabetesRenin-Angiotensin System StudiesHormonal Regulation and HypertensionCardiovascular, Neuropeptides, and Oxidative Stress Research