Interleukin‐33 and its receptor soluble suppression of tumorigenicity 2 in the diagnosis of gestational diabetes mellitus
Wei Fan, Wei Kang, Tao Li, Dandan Luo, Lei Huang, Yimei Yang, Yu Sun
Abstract
BACKGROUND: Gestational diabetes mellitus (GDM) is the most common pregnancy-related disease that increases the risk of metabolic disorders for the pregnancies and their offspring. GDM could be effectively prevented by early diagnosis and timely treatment. METHODS: 120 patients with GDM and 108 gestational week-matched pregnancies with normal glucose tolerance (NGT) were enrolled in our study. Their blood samples were collected, and demographic characteristics were analysed. RESULTS: Compared to NGT pregnancies, patients with GDM had increased the secretions of interleukin (IL)-33, soluble suppression of tumorigenicity 2 (sST2), IL-6 and tumour necrosis factor-α (TNF-α) in their plasma with elevated homeostatic model assessment (HOMA). Moreover, IL-33/sST2 was positively correlated with HOMA, IL-6 and TNF-α levels in the plasma of patients with GDM respectively. CONCLUSION: IL-33/sST2 might serve as a novel potential biomarker for early diagnosis of GDM.