IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery
Justine Faramia, Hao Zheng, Michael B. Mumphrey, R. Leigh Townsend, Stéphanie Miard, Anne‐Marie Carreau, Mélanie Nadeau, Frédérique Frisch, Elena‐Dana Baraboi, Thomas Grenier–Larouche, Christophe Noll, Meng Li, Laurent Biertho, Simon Marceau, Frédéric‐Simon Hould, Stéfane Lebel, Christopher D. Morrison, Heike Münzberg, Denis Richard, André C. Carpentier, André Tchernof, Hans‐Rudolf Berthoud, Frédéric Picard
Abstract
deficiency significantly impairs surgery-induced loss in adiposity and early improvement in insulin sensitivity but does not affect long-term enhancement in glucose homeostasis. This study demonstrates that the modulation of circulating IGFBP-2 may play a role in the early improvement of insulin sensitivity and loss of adiposity brought about by bariatric surgery.