Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea
Jie Wei, Xue Zhou, Mei Dong, Lufan Yang, Cheng Zhao, Ruili Lu, Guan‐Hu Bao, Fenglin Hu
Abstract
Abstract High-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analysis revealed that there are 20 main components in spores and mycelia extract of Cordyceps fumosorosea strain RCEF 6672 including mannitol ( 1 ), uridine ( 2 ), adenine ( 3 ). N 6 -(2-hydroxyethyl)-adenosine ( 4 ). N 6 -(2-hydroxyethylacetate)-adenosine ( 5 ), fumosoroseanoside A ( 6 ) and B ( 7 ), ovalicin-4α-alcohol ( 8 ), 1-linoleoyl-sn-glycero-3-phosphocholine ( 9 ) and its isomer ( 10 ), fumosoroseain A ( 11 ) and its isomer ( 12 ), 5 non-ribosomal peptides ( 13 to 17 ) and 3 fatty acids ( 18 to 20 ). The compounds 5 , 6 , 7 , 9 and 11 were prepared with preparative and semi-preparative HPLC and identified with 1D and 2D NMR. Compounds 4 and 5 were the first time identified from C. fumosorosea . Compounds 6 , 7 and 11 are novel compounds. Compounds 6 and 7 showed antibacterial and antifungal activities, and 11 showed antiaging activity. All the secondary metabolites ( 4 to 8 and 11 to 17 ) have strong bioactivities indicating that the metabolites have pharmaceutical development potentiality. Graphical Abstract