In vivo emergence of cefiderocol and ceftazidime/avibactam cross-resistance in KPC-producing Klebsiella pneumoniae following ceftazidime/avibactam -based therapies
Stefano Amadesi, Alberto Amedeo, Matteo Rinaldi, Marta Palombo, Maddalena Giannella, Paolo Gaibani
Abstract
We described the emergence of ceftazidime/avibactam and cefiderocol cross-resistance in patients with KPC-producing Klebsiella pneumoniae infections. All strains with ceftazidime/avibactam and cefiderocol cross-resistance showed point mutations on KPC Ω-loop. Taken together, our results indicate that prolonged exposure to ceftazidime/avibactam can confer cross-resistance to ceftazidime/avibactam and cefiderocol.
Topics & Concepts
Ceftazidime/avibactamKlebsiella pneumoniaeAvibactamCeftazidimeMicrobiologyBiologyAcquired resistanceMedicineDrug resistancePseudomonas aeruginosaBacteriaEscherichia coliGeneticsGeneAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyEnterobacteriaceae and Cronobacter Research