Synthesis of nuevamine and a cyano-chilenine analog <i>via</i> divergent C(sp<sup>3</sup>)–H bond functionalization of isoindolinone derivatives
Raúl A. Gómez-Prado, Ana L. Silva, Luis D. Miranda
Abstract
anion formation). Then, the isoindolobenzazepinic system of the chilenine skeleton was constructed by a Houben-Hoesch cyclization process. The present methodology has the advantage of not requiring the use of pre-functionalized substrates.
Topics & Concepts
ChemistryNitrileSurface modificationCombinatorial chemistryDerivative (finance)StereochemistryOrganic chemistryPhysical chemistryEconomicsFinancial economicsSynthesis and pharmacology of benzodiazepine derivativesCatalytic C–H Functionalization MethodsCancer therapeutics and mechanisms