1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors
A. Dolbois, R.K. Bedi, Elena Bochenkova, Anna Müller, Elena Moroz, Danzhi Huang, Amedeo Caflisch
Abstract
A/A level of polyadenylated RNA in MOLM-13 (acute myeloid leukemia) and PC-3 (prostate cancer) cell lines.
Topics & Concepts
ADMEChemistryFörster resonance energy transferPotencyMyeloid leukemiaRNAComputational biologyBiochemistryCombinatorial chemistryCancer researchStereochemistryIn vitroGeneFluorescenceBiologyQuantum mechanicsPhysicsRNA modifications and cancerCancer-related gene regulationRNA and protein synthesis mechanisms