Inflammation induces pro-NETotic neutrophils via TNFR2 signaling
Friederike S. Neuenfeldt, Jan Christoph Schumacher, Ricardo Grieshaber‐Bouyer, Jüri Habicht, Jutta Schröder–Braunstein, Annika Gauss, Uta Merle, Beate Niesler, Niko Heineken, Alexander H. Dalpke, Matthias M. Gaida, Thomas Giese, Stefan Meuer, Yvonne Samstag, Guido Wabnitz
Abstract
PMNs present in inflamed tissue in vivo and inducible in vitro. These cells may reflect an important component of tissue damage during chronic inflammation and could be of diagnostic value.
Topics & Concepts
Neutrophil extracellular trapsInflammationTumor necrosis factor alphaNeutrophil elastaseImmunologyElastaseLamina propriaIn vivoCell biologySignal transductionBiologyMedicinePathologyEpitheliumEnzymeBiotechnologyBiochemistryNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancerVasculitis and related conditions