Ball-Milling-Enabled Zn(OTf)<sub>2</sub>-Catalyzed Friedel–Crafts Hydroxyalkylation of Imidazo[1,2-<i>a</i>]pyridines and Indoles
Neha Meena, Bhawani, Sonam Sonam, Krishnan Rangan, Anil Kumar
Abstract
A facile and efficient synthetic method for the construction of C3-hydroxyalkylated imidazo[1,2- a ]pyridines and indoles by a Zn(OTf) 2 -catalyzed Friedel–Crafts hydroxyalkylation of imidazo[1,2- a ]pyridines and indoles with carbonyl compounds under mechanochemical conditions is reported. Good product selectivity, shorter reaction time, ambient reaction temperature, tolerance of a wide range of functional groups, broad substrate scope, moderate to good yield of products, and scalability are the salient features of the developed methodology.
Topics & Concepts
Friedel–Crafts reactionCatalysisChemistryYield (engineering)SelectivitySubstrate (aquarium)Combinatorial chemistryOrganic chemistryMedicinal chemistryMaterials scienceGeologyOceanographyMetallurgySynthesis and Reactivity of HeterocyclesCatalytic C–H Functionalization MethodsSynthesis and Characterization of Heterocyclic Compounds