Alzheimer’s disease and immunotherapy
Wei Qin, Yana Pang, Shuya Nie, Meina Quan, Jianping Jia
Abstract
Abstract Alzheimer's disease (AD) is the leading cause of dementia, characterized by neuropathological features such as amyloid-β (Aβ) plaques, neurofibrillary tau tangles, and neurodegeneration. Immunotherapy offers a promising potentially disease-modifying treatment for AD. We review recent advances in AD immunotherapy, specifically focusing on Aβ, tau, and neuroinflammation-targeted approaches, and gain insights from randomized controlled trials to propose disease-modifying directions.
Topics & Concepts
ImmunotherapyNeuroinflammationNeurodegenerationDiseaseDementiaMedicineAmyloid βNeuroscienceAlzheimer's diseaseTau pathologyPsychologyImmunologyPathologyImmune systemAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders