Method development and validation for simultaneous determination of six tyrosine kinase inhibitors and two active metabolites in human plasma/serum using UPLC–MS/MS for therapeutic drug monitoring
Menghua Zhang, Xiaoxue Liu, Zhiyao Chen, Shenhao Jiang, Lin Wang, Min Tao, Liyan Miao
Topics & Concepts
ChemistryChromatographySunitinibTherapeutic drug monitoringSelected reaction monitoringActive metaboliteTandem mass spectrometryBioanalysisHigh-performance liquid chromatographyElectrospray ionizationLiquid chromatography–mass spectrometrySolid phase extractionDasatinibMass spectrometryTyrosine kinasePharmacologyMetaboliteDrugBiochemistryReceptorMedicineOncologyRenal cell carcinomaChronic Myeloid Leukemia TreatmentsPI3K/AKT/mTOR signaling in cancerChronic Lymphocytic Leukemia Research