Summary of the clinical practice manual for <scp>late‐onset</scp> hypogonadism
Hisamitsu Ide, Yuko Akehi, Shinichiro Fukuhara, Shin Ohira, Sumito Ogawa, Tomoya Kataoka, Hiroshi Kumagai, Ko Kobayashi, Akira Komiya, Kazuyoshi Shigehara, Takahiro Syuto, Jintetu Soh, Makito Tanabe, Hisanori Taniguchi, Koji Chiba, Kazuhito Matsushita, Yozo Mitsui, Takahiro Yoneyama, Tomoya Shirakawa, Yasuhisa Fujii, Hiroaki Kumano, Hajime Ueshiba, Toshiyasu Amano, Haruaki Sasaki, Seiji Maeda, Atsushi Mizokami, Kazuhiro Suzuki, Shigeo Horie
Abstract
Testosterone plays an important role in maintaining both physical and mental function. Age-related testosterone depletion contributes to the development of angina, arteriosclerosis, obesity, metabolic syndrome, dementia, frailty, and a range of other conditions. A condition involving age-related testosterone depletion and the associated clinical symptoms is defined as late-onset hypogonadism (LOH). LOH is treated by testosterone replacement therapy. Indications for testosterone replacement therapy are determined by evaluating symptoms and signs.