Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief
Rui Zhang, Liang Cheng, Ziliang Dong, Linqian Hou, Shaohua Zhang, Zhouqi Meng, Oshra Betzer, Yihua Wang, Rachela Popovtzer, Zhuang Liu
Abstract
Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.
Topics & Concepts
NanodotNatural productAcute kidney injuryCoordination polymerOxidative stressKidneyMaterials sciencePolymerMedicineNanotechnologyChemistryBiochemistryInternal medicineComposite materialAcute Kidney Injury ResearchAdvanced Nanomaterials in CatalysisCarbon and Quantum Dots Applications