Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments
Noëmie Daniel, Laís R. Perazza, Thibault Varin, Jocelyn Trottier, Bruno Marcotte, Philippe St‐Pierre, Olivier Barbier, Benoît Chassaing, André Marette
Abstract
Selecting the most relevant control diet is of critical importance for metabolic and intestinal studies in animal models. Chow and LF-purified diet differentially impact metabolic and gut microbiome outcomes resulting in major changes in intestinal integrity in LF-fed animals which contributes to altering metabolic homeostasis. Dietary fat and low fiber both contribute to the deleterious metabolic effect of purified HF diets through both selective and overlapping mechanisms.
Topics & Concepts
Dietary fiberGut microbiomeBiologyObesityMetabolic pathwayGut floraEndocrinologyGut microfloraHomeostasisInternal medicineMetabolismBiochemistryFood scienceMedicineBacteriaGeneticsDiet and metabolism studiesDiet, Metabolism, and DiseaseLiver Disease Diagnosis and Treatment