Efficient synthesis of 3-hydroxy chromones via oxidative cyclization mediated by lipase
Jiapeng Li, Yue Yu, Yaning Xu, Fengxi Li, Yuqi Liu, Yifei Sun, Chunyu Wang, Peng Chen, Lei Wang
Abstract
In this work, an efficient synthesis of 3-hydroxy chromones was accomplished through oxidative cyclization mediated by lipase. This enzymatic process has salient features of environmental friendliness, mild reaction condition, satisfactory yield, green reusable biocatalyst, and short reaction time. The proposed method expands the application of lipase in organic synthesis.
Topics & Concepts
ChemistryLipaseYield (engineering)BiocatalysisOxidative phosphorylationOrganic chemistryCombinatorial chemistryEnzymeCatalysisReaction mechanismBiochemistryMaterials scienceMetallurgySynthesis of Organic CompoundsOxidative Organic Chemistry ReactionsSynthesis of Indole Derivatives