The synthesis, characterization, DNA/BSA/HSA interactions, molecular modeling, antibacterial properties, and<i>in vitro</i>cytotoxic activities of novel parent and niosome nano-encapsulated Ho(<scp>iii</scp>) complexes
Deng Yinhua, Mohammad Mehdi Foroughi, Zahra Aramesh‐Boroujeni, Shohreh Jahani, Mohadesh Peydayesh, Fariba Borhani, Mehrdad Khatami, Meysam Rohani, Michal Dušek, Václav Eigner
Abstract
molecular docking analysis. The antimicrobial activities of the Ho(iii) complex were tested against Gram-negative bacteria and Gram-positive bacteria. In addition, a niosome nano-encapsulated Ho(iii) complex was synthesized, and the parent and encapsulated complexes were evaluated as potential antitumor candidates. The main structure of the Ho(iii) complex is maintained after encapsulation using niosome nanoparticles. The MTT method was used to assess the anticancer properties of the Ho(iii) complex and its encapsulated form toward human lung carcinoma and breast cancer cell lines. The anticancer activity in the encapsulated form was more than that of the parent Ho(iii) complex. In conclusion, these compounds could be considered as new antitumor candidates.