A genome-wide CRISPR-based screen identifies <i>KAT7</i> as a driver of cellular senescence
Wei Wang, Yuxuan Zheng, Shuhui Sun, Wei Li, Moshi Song, Qianzhao Ji, Zeming Wu, Zunpeng Liu, Yanling Fan, Feifei Liu, Jingyi Li, Concepción Rodrı́guez Esteban, Si Wang, Qi Zhou, Juan Carlos Izpisúa Belmonte, Weiqi Zhang, Jing Qu, Fuchou Tang, Guang‐Hui Liu
Abstract
Inactivation of the histone acetyltransferase gene KAT7 prolongs survival in naturally aged mice and progeroid mice that age prematurely.
Topics & Concepts
CRISPRSenescenceHistone acetyltransferaseBiologyHistoneGenomeGeneGeneticsCell biologyCellular senescenceGenome editingPhenotypeTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsGenomics and Chromatin Dynamics