Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits
Jenolyn F. Alexander, Alexandre V. Seua, Luis D. Arroyo, Pradipta Ray, Andi Wangzhou, Laura Lückemann, Manfred Schedlowski, Theodore J. Price, Annemieke Kavelaars, Cobi J. Heijnen
Abstract
Our results provide key evidence on the therapeutic potential of isolated mitochondria - restoring both brain structure and function, their capability to enter brain meninges and parenchyma upon nasal delivery and undergo rapid cellular internalization and alter the hippocampal transcriptome. Our data identify nasal administration of mitochondria as an effective strategy for reversing chemotherapy-induced cognitive deficits and restoring brain health, providing promise for the growing population of both adult and pediatric cancer survivors.
Topics & Concepts
HippocampusMitochondrionNeuroscienceHippocampal formationPathologyMedicineBiologyCell biologyCancer-related cognitive impairment studiesGlioma Diagnosis and TreatmentBrain Metastases and Treatment