Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence
Sakshi Talwar, Manitosh Pandey, Chandresh Sharma, Rintu Kutum, Josephine Lum, Daniel Carbajo, Renu Goel, Michael Poidinger, Debasis Dash, Amit Singhal, Amit Kumar Pandey
Abstract
VapBC12 TA system acts as a molecular switch regulating persister generation during infection. VapBC12 TA system as a drug target offers opportunities to develop shorter and more effective treatment regimens against tuberculosis.
Topics & Concepts
AntitoxinPersistence (discontinuity)Drug resistanceToxinRegimenMedicineLocus (genetics)BiologyMicrobiologyInternal medicineGeneticsGeneGeotechnical engineeringEngineeringMycobacterium research and diagnosisTuberculosis Research and EpidemiologyAntibiotic Resistance in Bacteria