Proteomic investigation reveals dominant alterations of neutrophil degranulation and mRNA translation pathways in patients with COVID-19
Renuka Bankar, Kruthi Suvarna, Saicharan Ghantasala, Arghya Banerjee, Deeptarup Biswas, Manisha Choudhury, Viswanthram Palanivel, Akanksha Salkar, Ayushi Verma, Avinash Singh, Amrita Mukherjee, Medha Gayathri J. Pai, Jyotirmoy Roy, Alisha Srivastava, Apoorva Badaya, Sachee Agrawal, Om Shrivastav, Jayanthi Shastri, Sanjeeva Srivastava
Abstract
docking of potential drugs with host proteins involved in the interleukin-12 signaling pathway might aid in COVID-19 therapeutic interventions.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Degranulation2019-20 coronavirus outbreakTranslation (biology)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Messenger RNAChemistryComputational biologyCell biologyBiologyMedicineVirologyBiochemistryGenePathologyInfectious disease (medical specialty)OutbreakDiseaseReceptorCOVID-19 Clinical Research StudiesNeutrophil, Myeloperoxidase and Oxidative MechanismsLong-Term Effects of COVID-19