Hypertrophic cardiomyopathy
Murillo de Oliveira Antunes, Thiago Luis Scudeler
Abstract
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease. The disease is characterized by marked variability in morphological expression and natural history, ranging from asymptomatic to heart failure or sudden cardiac death. Left ventricular hypertrophy and abnormal ventricular configuration result in dynamic left ventricular outflow obstruction in most patients. The goal of pharmacological therapy in HCM is to alleviate the symptoms, and it includes pharmacotherapies and septal reduction therapies. In this review, we summarize the relevant clinical issues and treatment options of HCM.
Topics & Concepts
MedicineHypertrophic cardiomyopathyAsymptomaticCardiologySudden cardiac deathInternal medicineNatural historyHeart failureLeft ventricular hypertrophySudden deathDiseaseCardiomyopathyVentricular outflow tract obstructionMuscle hypertrophyBlood pressureCardiomyopathy and Myosin StudiesTrypanosoma species research and implicationsViral Infections and Immunology Research