FNIP1: A key regulator of mitochondrial function
Feng Zeng, Jiaying Cao, Wentao Li, Yanhong Zhou, Yuan Xia
Abstract
Folliculin interacting protein 1 (FNIP1), a novel folliculin interacting protein 1, is a key regulatory factor for mitochondrial function. FNIP1 mainly responds to energy signal transduction through physical interactions with 5′-AMP activated protein kinase (AMPK). Simultaneously, it affects the transcription of mitochondria-associated genes by regulating the lysosomal localization of mechanistic target of rapamycin kinase (mTORC1). This article takes FNIP1 as the core and first introduces its involvement in the development of B cells and invariant natural killer T (iNKT) cells, muscle fiber type conversion, and the thermogenic remodeling of adipocytes by regulating mitochondrial function. In addition we discuss the detailed impact of upstream regulatory factors of FNIP1 on its function. Finally, the impact of FNIP1 on the prognosis and treatment of clinically related metabolic diseases is summarized, aiming to provide a new theoretical basis and treatment plans for the diagnosis and treatment of such diseases. • FNIP1 is involved in B cell development by regulating mitochondrial autophagy. • FNIP1 affects B cell development by influencing AMPK/mTORC1 lysosomal localization. • FNIP1 participates in iNKT cell mitochondrial metabolism by regulating AMPK/mTOR. • FNIP1 and AMPK interactions might regulate myofiber type transition. • FNIP1 is a key factor in the negative regulation of thermogenesis in beige adipocytes.