Base-mediated [3 + 2]-cycloannulation strategy for the synthesis of pyrazolo[1,5-<i>a</i>]pyridine derivatives using (<i>E</i>)-β-iodovinyl sulfones
Raju Jannapu Reddy, Nunavath Sharadha, Arram Haritha Kumari
Abstract
]pyridines in moderate to high yields. Of note, the metal-free protocol features a broad substrate scope with good functional group tolerance and compatibility. The efficacy of the process was proved with gram-scale reactions, and a plausible mechanism is also presented based on concrete results.
Topics & Concepts
ChemistrySulfonylPyridiniumCombinatorial chemistryIodideImideCycloadditionStereochemistryMedicinal chemistryOrganic chemistryAlkylCatalysisSulfur-Based Synthesis TechniquesCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods