Oncomatrix: Molecular Composition and Biomechanical Properties of the Extracellular Matrix in Human Tumors
Ilya Klabukov, Anna N. Smirnova, Anna Yakimova, Alexander E. Kabakov, Dmitri Atiakshin, D. А. Petrenko, Victoria Shestakova, Yana Sulina, Elena Yatsenko, В. Н. Степаненко, Michael Ignatyuk, Е. С. Евстратова, М. Е. Крашенинников, Д. В. Сосин, Denis Baranovskii, С. А. Иванов, Peter Shegay, А. Д. Каприн
Abstract
The extracellular matrix is an organized three-dimensional network of protein-based molecules and other macromolecules that provide structural and biochemical support to tissues. Depending on its biochemical and structural properties, the extracellular matrix influences cell adhesion and signal transduction and, in general, can influence cell differentiation and proliferation through specific mechanisms of chemical and mechanical sensing. The development of body tissues during ontogenesis is accompanied by changes not only in cells but also in the composition and properties of the extracellular matrix. Similarly, tumor development in carcinogenesis is accompanied by a continuous change in the properties of the extracellular matrix of tumor cells, called ‘oncomatrix’, as the tumor matures, from the development of the primary focus to the stage of metastasis. In this paper, the characteristics of the composition and properties of the extracellular matrix of tumor tissues are considered, as well as changes to the composition and properties of the matrix during the evolution of the tumor and metastasis. The extracellular matrix patterns of tumor tissues can be used as biomarkers of oncological diseases as well as potential targets for promising anti-tumor therapies.